Espen Spangenburg, Ph.D.

Assistant Professor

Exercise Physiology

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The overall research goal of my laboratory is to define the molecular and physiological mechanisms activated by various hormones or cytokines in both skeletal muscle and adipose tissue that might influence the onset of these conditions. In addition, we also examine the influence physical activity has on the mechanisms that may regulate these conditions. Skeletal muscle and adipose tissue exist in a symbiotic relationship, in that changes in one tissue have the potential to affect the function of the other tissue. Currently, it is believed that this relationship is mediated by various hormones, cytokines, or growth factors released by these tissues. Physical activity can not only alter the release of these factors, but also affect the sensitivity of skeletal muscle and adipose tissue to these factors. To begin to understand the possible mechanisms that these releasable factors may regulate in muscle and adipose tissue my laboratory currently has two ongoing projects. First, my laboratory is examining the molecular regulation of signaling mechanisms activated by various hormones, cytokines, or growth factors in skeletal muscle and adipose tissue. Secondly, we are examining the contribution of menopause (or the loss of estrogens) to the development of sarcopenia (agerelated loss of muscle mass) and obesity.