James M. Hagberg , Ph.D.

Professor

Exercise Physiology

PUBLICATIONS

MS Bray, JM Hagberg, L Perusse, T Rankinen, SM Roth, B Wolfarth, C Bouchard. (2009).
The human gene map for performance and health-related fitness phenotypes: 2006-2007 update. Med Sci Sports Exercise 41: 34-72.

JM Hagberg. (2009).
Physical activity and hypertension in obesity. In: Advances in Physical Activity and Obesity. Ed: C Bouchard and PT Katzmarzyk. Human Kinettics Press: Champaign, IL, In Press

Feairheller DL, MD Brown, JY Park, TE Brinkley, S Basu, JM Hagberg, RE Ferrell, NM Fenty-Stewart. (2009).
Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exercise 41: 1421-1428

Y Yang, D Liu, DA Phares, EP Wiess, J Brandauer, JM Hagberg. (2008)
Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes. Exper Physiol 93: 95-103.

TE Brinkley, N Kume, H Matsuoka, DA Phares, T Kita, JM Hagberg. (2008).
Elevated soluble lectin-like oxidized LDL receptor 1 levels in obese postmenopausal women. Obesity (Silver Spring) 16: 1454-1456.

TJ Brinkley, N Kume, H Mitsuoka, MD Brown, DA Phares, RE Ferrell, T Kita, JM Hagberg. (2008).
Variation in the lectin-like oxidized LDL receptor 1 gene is associated with plasma soluble LOX-1 levels. Exp Physiol. 93: 1085-1090.

TO Obisesan, RE Ferrell, AP Goldberg, DA Phares, TJ Ellis, JM Hagberg. (2008).
APO E Genotype affects black-white responses of HDL cholesterol subspecies to aerobic
exercise training. Metabolism 57: 1669-1676.

EP Weiss, J Brandauer, O Kulaputana, IA Ghiu, CR Wohn, DA Phares, AR Shuldiner, JM Hagberg. (2007).
FABP2 Ala54thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary non-diabetic men and women. Am J Clin Nutr 85: 102-108.

S Witkowski, JM Hagberg. (2007).
Editorial – Progenitor cells and age: can we fight aging with exercise. J Appl Physiol 102: 834-835.

SJ Prior, LJ Joseph, J Brandauer, LI Katzel, JM Hagberg, AS Ryan. (2007).
Reduction in mid-thigh low-density muscle with aerobic exercise training and weight loss impacts glucose tolerance in older men. J Clin Endocrinol Metabolism 92: 880-886.

A Halverstadt, DA Phares, KR Wilund, AP Goldberg, JM Hagberg. (2007).
Endurance exercise training raises HDL-cholesterol and lowers small LDL-C and VLDL-C independent of body fat phenotypes in older men and women. Metabolism. 56: 444-450.

MM Lockard, R Gopinathannair, CM Paton, DA Phares, JM Hagberg. (2007).
Exercise training-induced changes in coagulation factors in older adults. Med Sci Sports Exercise 39: 587-592.

JY Park, IKG Farrance, NM Fenty, JM Hagberg, SM Roth, H Jo, SR Brant, DM Moser, MD Brown. (2007).
NFKB1 gene promoter variation alters shear-induced endothelial nitric oxide synthase gene expression and endothelial function in pre- and Stage 1 hypertensives. Am J Physiol. 293: H2320-H2327.

BD Hand, M Kostek, R Ferrell, M Delmonico, L Douglass, S Roth, JM Hagberg, B Hurley. (2007).
Influence of the insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults. J Appl Physiol. 103: 1678-1687.

T Rankinen, MS Bray, JM Hagberg, L Perusse, SM Roth, B Wolfarth, C Bouchard. (2006).
The human gene map for performance and health-related fitness phenotypes: 2005 update. Med Sci Sports Exercise 38: 1863-1888.

A Halverstadt, S Walsh, S Roth, RE Ferrell, JM Hagberg. (2006).
Identification of a novel mutation combination in Factor XIII deficiency: Genetic update to the first reported case in the United States. Int J Hematology 83: 144-146.

SB Racette, EM Evans, EP Weiss, JM Hagberg, JO Holloszy. (2006).
Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50 to 95 year olds. Diabetes Care 29: 673-678.

TO Obisesan, C Leeuwenburgh, RE Ferrell, DA Phares, JA McKenzie, SJ Prior, JM Hagberg. (2006).
C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity. Metabolism 55:453-460.

CM Paton, J Brandauer, EP Weiss, MD Brown, FM Ivey, SM Roth, JM Hagberg. (2006).
Hemostatic response to postprandial lipemia before and after exercise training. J Appl Physiol 101: 316-321.

O Kulaputana, I Ghiu, DA Phares, RF Macko, AP Goldberg, RE Ferrell, JM Hagberg. (2006).
Genetic markers of fibrinolytic responses of older persons to exercise training. Int J Sports Med 27: 617-622.

SJ Prior, JM Hagberg, CM Paton, LW Douglass, MD Brown, JC McLenithan, SM Roth. (2006).
DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption. Am J Physiol Heart Circ Physiol. 290: H1848-H1855.

BD Hand, SM McCole, MD Brown, JJ Park, RE Ferrell, A Huberty, LW Douglass, JM Hagberg. (2006).
eNOS gene polymorphisms and exercise hemodynamics in postmenopausal women. Int J Sports Med 27: 951-958.

O Kulaputana, R Macko, I Ghiu, DA Phares, AP Goldberg, JM Hagberg. (2005).
Human gender differences in fibrinolystic responses to exercise training and their physiological determinants. Exper Physiol 90: 881-887.

JY Park, RE Ferrell, JJ Park, JM Hagberg, DA Phares, JM Jones, MD Brown. (2005).
NADPH oxidase p22phox gene variants are assosiated with systemic oxidative stress biomarker responses to exercise training. J Appl Physiol. 99:1905-1911.

B Wolfarth, MS Bray, JM Hagberg, JM Hagberg, L Perusse, R Rauramaa, MA Rivera, SM Roth, T Rankinen, C Bouchard. (2005).
The human gene map for performance and health-related fitness phenotypes: 2004 update. Med Sci Sports Exercise 37: 881-903.

MH Roltsch, MD Brown, BD Hand, M Kostek, DA Phares, A Huberty, LW Douglass, RE Ferrell, JM Hagberg. (2005).
No association between ACE I/D polymorphism and cardiovascular hemodynamics during exercise in young women. Int J Sports Med. 26: 638-644.

A Halverstadt, DA Phares, RE Ferrell, AP Goldberg, JM Hagberg. (2005).
Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise training. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1734: 143-151.

KM Rabon-Stith, JM Hagberg, DA Phares, MC Kostek, MJ Delmonico, SM Roth, RE Ferrell, JM Conway, AS Ryan, BF Hurley. (2005).
Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. Experimental Physiol. 90: 653-661.

EP Weiss, O Kulaputana, IA Ghiu, J Brandauer, CR Wohn, R Gopinathannair, DA Phares, AR Shuldiner, JM Hagberg. (2005).
Effects of PPARgamma genotype and sex on endurance training-induced changes in insulin response to oral glucose. Metabolism 54: 97-102.

JA McKenzie, EP Weiss, DA Phares, RE Ferrell, JM Hagberg. (2004).
Influence of the interleukin-6 -174G/C gene polymorphism on exercise training-induced changes in glucose tolerance indices.J Appl Physiol 97: 1338-1342.

TO Obisesan, C Leeuwenburgh, T Phillips, RE Ferrell, DA Phares, SJ Prior, JM Hagberg. (2004).
C-Reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reacitve protein levels. IArterioscl Thromb Vasc Biol. 24: 1874-1879.

DA Phares, AA Halverstadt, AR Shuldiner, RE Ferrell, LW Douglass, AS Ryan, AP Goldberg, JM Hagberg. (2004).
Association between body fat response to exercise training and multilocus adrenergic receptor genotypes. Obesity Research 12: 807-815.

EP Weiss, JJ Park, JA McKenzie, JY Park, O Kulaputana, MD Brown, DA Phares, JM Hagberg. (2004).
Plasma nitrate/nitrite response to an oral glucose load and the effect of endurance training. Metabolism. 53: 673-679.

I Ghiu, RE Ferrell, O Tiyasangthong, DA Phares, JM Hagberg. (2004).
Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training. J Appl Physiol: 96: 985-990.

SD McCole, AR Shuldiner, MD Brown, GE Moore, RE Ferrell, KR Wilund, JM Hagberg. (2004).
?2- and ?3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women. J Appl Physiol 96: 526-530.

A Halverstadt, DA Phares, RE Ferrell, KR Wilund, AP Goldberg, JM Hagberg. (2003).
High-density lipoprotein-cholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotype. Metabolism 52: 1505-1511.

SJ Prior, JM Hagberg, DA Phares, MD Brown, L Fairfull, RE Ferrell, SM Roth. (2003).
Sequence variation in hypoxia-inducible factor 1: association with maximal oxygen consumption. Physiol Genomics: 15: 20-26.

Hagberg, J.M., S.D. McCole, M.D. Brown, R.E. Ferrell, K.R. Wilund, & G.E. Moore. (2002).
ACE insertion/deletion polymorphism and submaximal exercise hemodynamics in postmenopausal women. J Appl Physiol 92: 1083-1088.

Hillman, C.H., E.P. Weiss, J.M. Hagberg, & B.D. Hatfield. (2002).
Cardiovascular fitness and neurocognitive processes in older adults. Psychophysiology 39: 303-312.

McCole, S.D., M.D. Brown, G.E. Moore, R.E. Ferrell, K.R. Wilund, & J.M. Hagberg. (2002).
Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women. Physiol Genomics 10: 63-69.

Weiss, E.P., M.D. Brown, A.R. Shuldiner, & J.M. Hagberg. (2002).
Fatty acid binding protein - 2 gene variants and insulin resistance: gene and gene-environment interaction effects. Physiological Genomics 10: 145-157.

Wilund, K.R., P.L. Colvin, D.A. Phares, A.P. Goldberg, & J.M. Hagberg. (2002).
Effect of endurance exercise training on plasma LpAI and LpAI:AII concentrations in sedentary adults. Metabolism 51: 1053-1060.

Wilund, K.R., R.E. Ferrell, D.A. Phares, A.P. Goldberg, & J.M. Hagberg. (2002).
Changes in HDL-C subfractions with exercise training may be dependent on CETP genotype. Metabolism 51: 774-778.

Hagberg, J.M., G.E. Moore, & R.E. Ferrell. (2001).
The genetics of human performance. Exercise and Sport Sciences Reviews, 29: 15-19.

Hagberg, J.M., J.M. Zmuda, S.D. McCole, K.S. Rodgers, R.E. Ferrell, K.R. Wilund, & G.E. Moore. (2001).
Determinants of bone mineral density in postmenopausal women. J Am Geriatrics Society 49: 1411-1417.

Brown, M.D., A.R. Shuldiner, R.E. Ferrell, E.P. Weiss, M.T. Korytkowski, J.M. Zmuda, S.D. McCole, G.E. Moore, & J.M. Hagberg. (2001).
FABP2 is associated with insulin sensitivity in older women. Metabolism 50: 1102-1105.

Moore, G.E., R.E. Ferrell, J.M. Zmuda, S.D. McCole, A.R. Shuldiner, & J.M. Hagberg. (2001).
Obesity gene selective for elite women athletes. Metabolism 50: 1391-1392.

Roltsch, M.H., T. Mendez, K.R. Wilund, & J.M. Hagberg. (2001).
Acute resistive exercise does not affect ambulatory blood pressure in young men and women. Med Sci Sports Exercise 33: 881-886.

Hagberg, J.M., K.R. Wilund, & R.E. Ferrell. (2000).
Gene and gene-environment interactive effects of APO E genotype on plasma lipoprotein lipids. Physiological Genomics. 4: 101-108.

Goldberg, A. P., Busby-Whitehead, M. J., Katzel, L. I., Krauss, R. M., Lumpkin, M., & Hagberg, J. M. (2000).
Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men. Journal of Gerontology: Medical Sciences, 55(6), 342-349.

McCole, S. D., Brown, M. D., Moore, G. E., Zmuda, J. M., Cwynar, J. D., & Hagberg, J. M. (2000).
Enhanced cardiovascular hemodynamics in endurance-trained postmenopausal women athletes. Medicine & Science in Sports and Exercise, 32(6): 1073-1079.

Taylor-Tolbert, N. S., Dengel, D. R., Brown, M. D., McCole, S. D., Pratley, R. E., Ferrell, R. E., & Hagberg, J. M. (2000).
Ambulatory blood pressure after acute exercise in older men with essential hypertension. American Journal of Hypertension, 13(1): 44-51.

Caldwell, G. E., Hagberg J. M., McCole, S. D., & Li, L. (1999).
Lower extremity joint movements during uphill cycling. Journal of Applied Biomechanics, 15, 166-181.

Hagberg, J. M. Ferrell, R. E., Dengel, D. R., & Wilund, K. R. (1999).
Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent. Hypertension, 34, 18-23.

McCole, S. D., Brown, M. D., Moore, G. E., Zmuda, J. M., Cwynar, J. D., & Hagberg, J. M. (1999)
Cardiovascular hemodynamics with increasing exercise intensities in postmenopausal women. Journal of Applied Physiology, 87(6): 2334-2340.

Hagbereg, J. M., Ferrell, R. E., Katzel, L. I., Dengel, D. R., Sorkin, J. D. & Goldberg, A. P. (1999)
Apolipoprotein E genotype and exercise training-induced increases in plasma High-Density Lipoprotein (HDL)- and HDL2-Cholesterol levels in overweight men. Metabolism, 48(8), 943-945.

Ferrell, R. E., Conte, V., Lawrence, E. A., Roth, S. M., Hagberg, J. M., & Hurley, B. F. (1999).
Frequent sequence variation in the human myostatin gene as a marker for analysis of muscle related phenotypes. Genomics, 62, 203-207.

Hagberg, J. M. (1996).
Physical activity, physical fitness, and blood pressure. In: Physical Activity and Cardiovascular Health: A National Consensus. Ed: A. Leon. Human Kinetics Press: Champaign, IL, In Press.

Schulman, S. P., Fleg, J. L., Goldberg, A. P., Busby-Whitehead, J., Hagberg, J. M., O'Conor, F. C., Gerstenblith, G., Becker, L. C., & Lakatta, L. E. (1996).
The continuum of cardiovascular performance across a broad range of fitness levels in healthy older men. Circulation, 94, 359-367.

Kang, J., Robertson, R. J., Hagberg, J. M., Kelley, D. E., Goss, F. L., DaSilva, S. G., Sluminski, R. R., & Utter, A .C. (1996).
Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients. Diabetes Care, 19, 341-349.

Brown, M. D., & Hagberg, J. M. (1995).
Does exercise training play a role in the treatment of essential hypertension. IJ Cardiovascular Risk, 2, 296-302.

Dengel, D. R., Hagberg, J. M., Coon, P. J., Drinkwater, D. T., & Goldberg, A. P. (1994).
Comparable effects of diet and exercise on body composition and lipoproteins in older men. Medicine and Science in Sports and Exercise, 26, 1307-1315.

Hagberg, J., Blair, S., Ehsani, A., Gordon, N., Kaplan, N., Tipton, C., & Zambraski, E. (1993).
American College of Sports Medicine Position Stand: Physical activity physical fitness, and hypertension. Medicine and Science in Sports and Exercise, 25, i-x.