A headshot of Daniel Shill
September 19, 2019

DISSERTATION PROPOSAL MEETING

Thursday, October 3rd, 2019 at 1:00PM
KNES Conference Room (SPH 2334)

TITLE:
Physical Inactivity Reductions in Subclinical Endothelial Function are Rescued by Pharmacologically Augmenting Glycolysis

Daniel Shill, PhD Candidate - Exercise Physiology

 

 

 

ADVISORY COMMITTEE:
Dr. James M. Hagberg, Chair
Dr. Steven M. Jay
Dr. Sarah Kuzmiak-Glancy
Dr. Alisa Morss Clyne
Dr. Steven J. Prior
Dr. Sushant M. Ranadive

ABSTRACT:
The proposed dissertation research is comprised of three investigations to determine the effect of physical activity-induced circulating factors and endothelial cell glycolysis on indices of endothelial function.  Importantly, the human subjects recruited for this dissertation research were young and free of traditional cardiovascular disease risk factors, except for physical inactivity.  The purpose of Specific Aim 1 was to determine if circulating factors altered by physical activity confer subclinical atheroprotective effects to the vasculature via beneficial changes in endothelial function.  The purpose of Specific Aim 2 was to determine if genetic enhancements in glycolysis could rescue function in endothelial cells exposed to serum from sedentary individuals.  The purpose of Specific Aim 3 is to determine if pharmacological enhancements in glycolysis could restore function in endothelial cells exposed to serum form sedentary individuals.  Collectively, it is anticipated these proposed studies will advance our understanding of the effect of physical activity and endothelial cell glycolysis on vascular function.    

Related People
Daniel Shill
Related Degree: 
PhD, Kinesiology