My research interests are in the assembly and transmission of virus particles. I am particularly interested in the molecular mechanisms that occur in order for influenza to assemble an infectious virus particle and for that particle to transmitted from one host to another. My previous work focused on the role of the cytoplasmic tail of the influenza M2 protein in the incorporation of the internal virus components. I have identified individual amino acids in the M2 cytoplasmic tail that are critical for that function, and future work will focus on identifying why those residues are critical. More recently, I have worked as part of a multidisciplinary team to capture and quantify influenza virus particles from infected human volunteers during an epidemic. In future work in this area, I would like to apply this technology to animal models of influenza (or other viruses) to begin to identify the molecular determinants of influenza aerosol generation.
I am also involved in an interdisciplinary effort to identify biomarkers that might be carried by a person who seeks to develop an influenza-base bioweapon. My role in this effort is to try to identify immune and microbiome signatures that are representative of someone who is engaged in influenza gain-of-function research.
Postdoctoral Fellow - Johns Hopkins Bloomberg School of Public Health - Baltimore, MD
Postdoctoral Research Assistant - Washington University Medical School - St Louis, MO
Ph.D., Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, LA
B.S., Biology and Chemistry, Emporia State University - Emporia, KS
MIEH 321 - Syphilis to SARS: Climate Change, Development and Emergence of Infectious Diseases
Taught online in 2012, In-person at the Shady Grove campus in 2013 and 2014 and on the College Park Campus in 2015
SPHL 415 - Public Health Biology
Taught as a hybrid course on the Shady Grove campus in 2014
Milton DK, Fabian MP, Cowling BJ, Grantham ML, McDevitt JJ (2013) Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks. PLoS Pathog 9(3): e1003205. doi:10.1371/journal.ppat.1003205.
Grantham ML, Stewart SM, Lalime EN & Pekosz A. Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for the production of infectious virus particles. (2010) Tyrosines in the influenza a virus m2 protein cytoplasmic tail are critical for production of infectious virus particles. J Virol. 84, 8765-76.
Grandea AG III, Olsen OA, Cox TC, Renshaw M, Hammond PW, Chan-Hui P-Y, Mitcham J, Cieplak W, Stewart SM, Grantham ML, Pekosz A, Hatta M, Kawaoka Y, & Moyle M. Human Antibodies Reveal a Protective Epitope that is Highly Conserved Among Human and Non-Human Influenza A Viruses. PNAS. 107, 12658-63.
Grantham ML, Wu WH, Lalime EN, Lorenzo M, Klein SL & Pekosz A. (2009) Palmitoylation of the influenza A virus M2 protein is not required for virus replication in vitro but contributes to virus virulence. J Virol. 83, 8655-61.
Muggeridge MI, Grantham ML & Johnson FB, (2004). Identification of syncytial mutations in a clinical isolate of herpes simplex virus 2. Virology 328, 244-253.
Fan ZF, Grantham ML, Smith MS, Anderson EA, Cardelli JA & Muggeridge MI. (2002). Truncation of herpes simplex virus type 2 glycoprotein B increases its cell surface expression and activity in cell-cell fusion, but these properties are unrelated. J Virol. 76, 9271-83.