Campus: UMD | Building: School of Public Health | Room: 2234M
Phone: (301) 405-6421 |
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Wed 2-4pm, or appointment by email


His primary research interest focuses on developing statistical methods for the high-dimensional biomedical data with complex spatial and temporal structure (e.g. neuroimaging data and mass spectrometry data). Currently, he is working on developing statistical/graphical models for network data analysis.

Education and Training

2003 B.S., Harbin Institute of Technology Electrical Engineering

2004 M.S., East Tennessee State University Mathematics and Statistics

2012 MSPH, Emory University Biostatistics and Bioinformatics

2012 Ph.D., Emory University Biostatistics and Bioinformatics


EPIB 651: Biostatistics II (Syllabus)

EPIB 652: Categorical Data Analysis

EPIB 698G: Bayesian Data Analysis

EPIB 657: Spatial Statistics

EPIB 789: Statistical Consulting

Honors and Awards

David Byar Young Investigator Award Competition Travel Award, American Statistical Association, Biometrics Section, JSM 2012.

Statistical Learning and Data Mining Paper Competition winner, American Statistical Association,

Data Mining and Machine Learning Section, JSM 2011.

Livingston Fellowship, Emory University, 2011.

Organization of Human Brain Mapping Trainee Abstract Award, 2009.


Selected Publications

*: corresponding author;  + graduate student or advisee

Kochunov P, Coyle TR, Rowland LM, Jahanshad N, Thompson PM, Kelly S, Du X, Sampath H, Bruce H, Chiappelli J, Ryan M, Fisseha F, Savransky A, Adhikari B, Chen S, Paciga SA, Whelan CD, Xie Z, Hyde CL, Chen X, Schubert CR, O’Donnell P, Hong LE. Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia. JAMA Psychiatry. Published online August 02, 2017. doi:10.1001/jamapsychiatry.2017.2228

Chiappelli J, Chen S , Hackman A,  Hong LE (2017)  Evidence for differential opioid use disorder in schizophrenia in an addiction treatment population, Schizophrenia Research, Schizophrenia Research, doi: 10.1016/j.schres.2017.05.004

Chen S* , Xing Y and Kang J (2017). Latent and Abnormal Functional Connectivity Circuits in Autism Spectrum Disorders. Front. Neurosci. 11:125. doi: 10.3389/fnins.2017.00125

Chen S*,  Bowman  F.D.,  and  Mayberg  H.  (2016).   A Bayesian  Hierarchical  Framework  for Modeling  BrainConnectivity for Neuroimaging  Data,  Biometrics, 72. 2.  . DOI: 10.1111/biom.12433

Chen S*,  Kang J, Xing Y+, and Wang G+,  (2015). A parsimonious statistical method to detect group-wise differentially expressed functional connectivity networks,  Human Brain Mapping, 36(12), 5196–5206. DOI: 10.1002/hbm.23007

Chen S*,  Kang J, and Wang, G+,  (2015). An empirical  Bayes normalization method  for connectivity metrics in resting  state  fMRI data,  Frontiers in Neuroscience, 9, 316. doi: 10.3389/fnins.2015.00316

Huang,  C.,  Guo,  C.,  Nichols,  C.,  Chen S,  and  Martorell  R..  Elevated  levels of protein  in urine  in adulthood after  exposure  to the  Chinese famine of 1959-61 during  gestation and  the  early postnatal period, International Journal of Epidemiology43(6):1806-14.

Burke D, Bell RB, Easley KA, Chen S, Samir A, and Burke D., "The effect of body mass index on stroke rehabilitation", Archives of Physical Medicine and Rehabilitation, 95 (6), 1055–1059, 2014

He, X., Lu, X., Chen, S., Hochberg, M. C., and Lee, M.-L. T., "Association between obesity, race and knee osteoarthritis: The Multicenter Osteoarthritis Study", International Journal of Statistics in Medical Research, 3, 224-230, 2014

Chen S*, Grant E+, Wu T, and Bowman FD, Machine Learning Methods for Longitudinal High Dimensional Data, accepted by WIREs Computational Statistics 6(1) 10-18, 2014.

Raison C, Rutherford R, Woolwine B, Chen S, Schettler P, Drake D, Haroon E, Miller A, A Randomized Controlled Trial of the Tumor Necrosis Factor-alpha Antagonist Infliximab in Treatment Resistant Depression: Role of Baseline Inflammation, Archives of General Psychiatry, 70(1):31–41 2013.

Bowman FD, Derado G, and Chen S, Determining Functional Connectivity using fMRI Data with Diffusion-Based AnatomicalWeighting, NeuroImage, 62, 1769–1779, 2012.

Bouloux G,  Chen S, Easley K, et al.  Treatment of Mandibular Fractures in a level I trauma center,Journal of Oral  and Maxillofacial Surgery,  70(7) 1613–21, 2012.

Anderson A, Chane T, Patel P, Chen S, Xue W, Easley K, Warfarin therapy in HIV-infected individuals: data from the medical home model, AIDS Patient Care and STDs, 26(8):454–62, 2012.

Zhang L, Agravat S, Derado G, Chen S, Bowman FD, BSmac: a MATLAB toolbox Implementing a Bayesian Spatial model for Brain activation and Connectivity Journal of Neuroscience Methods, 204(1), 133-143, 2011.

Chen S* and Bowman FD, A Novel Support Vector Classifier for Longitudinal High Dimensional Data, Statistical Analysis and Data Mining 4(6) 604–611, 2011.

Li M, Chen S, Zhang X, Chen H, and Shyr Y,Wave-spec: a preprocessing package for mass spectrometry data, Bioinformatics 27(5): 739-740, 2011.

Woodham  DC,  Kenyon  N, Bell SC, Alford RA,  Chen S,  Billheimer  D, Shyr  Y, Rollins-Smith  LA, Adaptations of skin peptide  defences and possible response to the amphibian chytrid  fungus in popu- lations  of Australian green-eyed treefrogs,  Litoria  genimaculata, Diversity  and Distributions V16 (4):703-712, 2010.

Chen S, Li M, Hong D, Billheimer D, Li H, and Shyr Y, A Novel Comprehensive Wave-form MS data Processing Method, Bioinformatics, 25(6):808-814, 2009.

Salmon  S, Chen  H,  Chen S, Herbst  R, Tsao  R, Tran  H, Sandler  A, Billheimer  D, Shyr Y, Lee JW, Massion P, Brahmer  J, Schiller J, Carbone  D, and Dang T, Classification  By Mass Spectrometry Can Accurately And  Reliably  Predict Outcome  In  Patients With  Non-Small  Cell Lung  Cancer Treated With  Erlotinib Containing Regimen,  Journal of Thoracic Oncology, 4(6):689-696 2009.

Liu C, Agrawal P, Sarkar R, and Chen S, Dynamic Difficulty Adjustment in Computer Games through Real-Time Anxiety-based Affective Feedback, International Journal of Human-Computer Interaction, Volume 25(6): 506 - 529, 2009.

Chen S, Hong D, and Shyr Y, Wavelets-based Procedures for Proteomic Mass Spectrometry Data Processing, Computational Statistics and Data Analysis, 52 211-220, 2007.

Agulnik M, Cunha-Santos G, Hedley D, Nicklee T, Reis PP,  Ho J, Pond GR, Chen H, Chen S, Shyr Y, Winquist  E, Soulieres D, Chen EX, Squire JA, Marrano  P, Kamel-Reid  S, Dancey J, Siu LL, Tsao MS, Predictive and  Pharmacodynamic Biomarker  Studies  in Tumor  and  Skin Tissue  Samples  of Patients with  Recurrent or Metastatic Squamous  Cell Carcinoma of the  Head and  Neck treated by Erlotinib, Journal of Clinical  Oncology, 25(16):2184-90, 2007.

Yildiz P, Shyr Y, Rahman SMJ, Wardwell NR, Zimmerman  LJ, Shakhtour B,Gray  WH,Li H,  Chen S, Moore JH, Liebler DC, Bigbee WL, Siegfried JM, Weissfeld JL, Gonzalez AL, Ninan M, Johnson  DH, Carbone  DP,  Caprioli  RM  and  Massion  PP,  Diagnostic  Accuracy  of MALDI  Mass Spectrometric Analysis  of Unfractionated Serum  in  Lung  Cancer,  Journal of Thoracic Oncology.   2(10):893-901, 2007.

Oh H, Hatfield BD, Jaquess KJ, Lo L-C, Tan YY, Prevost MC, Mohler JM, Postlethwaite H, Rietschel JC, Miller MW, Postlethwaite H, Blanco JA, Chen S, Gentili RJ. (2015). A composite cognitive workload assessment system in pilots under various task demands using ensemble learning. Proceedings of the 17th Human-Computer Interaction Conference. Foundations of Augmented Cognition. Lecture Notes in Computer Science, 9183), 91-100, 2-7 August, Los Angeles, USA, in press.

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