Location: Atlantic Building Room 2330
Smoking cessation has been proven to be associated with a reduced risk of chronic diseases, such as cardiovascular disease, chronic obstructive pulmonary disease, and cancer. However, its
relationship with type 2 diabetes mellitus (T2DM) remains complex. Weight gain following
smoking cessation has been identified as a key mediator that may offset some of the metabolic
benefits of quitting. Previous studies have reported inconsistent findings, largely due to
inadequate handling of time-varying exposures, confounders, mediators, and potential selection
bias from informative censoring. This dissertation applies marginal structural models (MSMs)
and the parametric mediational g-formula to address these methodological limitations and
investigate the temporal relationships between smoking cessation, weight change, and T2DM
risk.